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PubMed · 16153832

Pyrazolopyridinones as functionally selective GABAA ligands.

Wesley P Blackaby·John R Atack·Frances Bromidge·Richard Lewis·Michael G N Russell·Alison Smith·Keith Wafford·Ruth M McKernan·Leslie J Street·José L Castro
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Abstract

2,5-Dihydro-3H-pyrazolo[4,3-c]pyridin-3-ones are GABAA receptor benzodiazepine binding site ligands, which can exhibit functional selectivity for the alpha3 subtype over the alpha1 subtype. SAR studies to optimize this functional selectivity are described.

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Azo CompoundsLigandsMolecular StructurePyridinesReceptors, GABA-ASensitivity and SpecificityStructure-Activity RelationshipSubstrate SpecificityJournal Article

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Wesley P Blackaby, John R Atack, Frances Bromidge, Richard Lewis, Michael G N Russell, Alison Smith, Keith Wafford, Ruth M McKernan, Leslie J Street, José L Castro. 2005-11-15. Pyrazolopyridinones as functionally selective GABAA ligands.. https://doi.org/10.1016/j.bmcl.2005.08.006

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