Matrix metalloproteinases in isolated hypercholesterolemia.

J Malik; T Stulc; R Ceska

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PubMed · 16158043

Matrix metalloproteinases in isolated hypercholesterolemia.

J Malik·T Stulc·R Ceska

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Abstract

AIM: Levels of circulating matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are altered in subjects with atherosclerosis. We hypothesized that also otherwise healthy hypercholesterolemic subjects will have altered MMP/TIMP concentrations. To validate this hypothesis, we compared MMPs/TIMPs in patients with moderate isolated hypercholesterolemia before and after atorvastatin therapy and in healthy normolipidemic controls. METHODS: Twenty-seven otherwise healthy subjects with isolated hypercholesterolemia (total cholesterol 8.3+/-0.3 mmol/L) and 29 healthy normolipidemic controls were included. Patients were treated by atorvastatin for 10 weeks. We studied plasma levels of MMPs (MMP)-2, -3, and -9 and of their TIMPs (TIMP)-1 and -2. RESULTS: Patients differed from controls by significantly lower MMP-3 [11.6 (5.7-21) vs 18.4 (12-22) ng/mL, P<10-4 (median, range 25-75%)] and TIMP-2 [13.3 (8.8-30.5) vs 22.1 (10.8-39) ng/mL, P=0.02] and by higher TIMP-1 [496 (461-538) vs 483 (456-500) ng/mL, P=0.004]. Atorvastatin decreased significantly TIMP-1 [from 496 (461-538) to 476 (451-525) ng/mL]. CONCLUSIONS: Isolated hypercholesterolemia per se is associated with similar alterations of circulating MMPs and TIMPs as developed symptomatic atherosclerosis. Most consistent link to serum lipids was observed in case of TIMP-1. MMP and TIMP levels probably reflect the atherogenic process in its early stages in these subjects.

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Atherosclerosis Atorvastatin Female Heptanoic Acids Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Hypercholesterolemia Male Matrix Metalloproteinases Middle Aged Pyrroles Tissue Inhibitor of Metalloproteinase-1 Tissue Inhibitor of Metalloproteinases Journal Article Research Support, Non-U.S. Gov't

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J Malik, T Stulc, R Ceska. 2005. Matrix metalloproteinases in isolated hypercholesterolemia.. https://pubmed.ncbi.nlm.nih.gov/16158043/

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