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Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry.

Dirk T S Rijkers·G Wilma van Esse·Remco Merkx·Arwin J Brouwer·Hans J F Jacobs·Roland J Pieters·Rob M J Liskamp
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Abstract

Multivalent dendrimeric peptides were synthesized via a microwave-assisted Huisgen 1,3-dipolar cycloaddition between azido peptides and dendrimeric alkynes in yields ranging from 46 to 96%.

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AzidesCyclizationDendrimersElectrophoresis, Polyacrylamide GelMagnetic Resonance SpectroscopyMicrowavesPeptidesSolventsSpectrometry, Mass, Electrospray IonizationJournal Article

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Dirk T S Rijkers, G Wilma van Esse, Remco Merkx, Arwin J Brouwer, Hans J F Jacobs, Roland J Pieters, Rob M J Liskamp. 2005-08-19. Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry.. https://doi.org/10.1039/b507975f

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