Compositional variation in bacterial genes and proteins with potential expression level.

Sabyasachi Das; Subhagata Ghosh; Archana Pan; Chitra Dutta

doi:10.1016/j.febslet.2005.08.042

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Compositional variation in bacterial genes and proteins with potential expression level.

Sabyasachi Das·Subhagata Ghosh·Archana Pan·Chitra Dutta

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Abstract

Usage of guanine and cytosine at three codon sites in eubacterial genes vary distinctly with potential expressivity, as predicted by Codon Adaptation Index (CAI). In bacteria with moderate/high GC-content, G(3) follows a biphasic relationship, while C(3) increases with CAI. In AT-rich bacteria, correlation of CAI is negative with G(3), but non-specific with C(3). Correlations of CAI with residues encoded by G-starting codons are positive, while with those by C-starting codons are usually negative/random. Average Size/Complexity Score and aromaticity of gene-products decrease with CAI, confirming general validity of cost-minimization principle in free-living eubacteria. Alcoholicity of bacterial gene-products usually decreases with expressivity.

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Amino Acids Bacterial Proteins Codon Gene Expression Regulation, Bacterial Genes, Bacterial Molecular Sequence Data Open Reading Frames Journal Article Research Support, Non-U.S. Gov't

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Sabyasachi Das, Subhagata Ghosh, Archana Pan, Chitra Dutta. 2005-09-26. Compositional variation in bacterial genes and proteins with potential expression level.. https://doi.org/10.1016/j.febslet.2005.08.042

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