Calciuria and preeclampsia: a case-control study.

Valérie Szmidt-Adjidé; Françoise Vendittelli; Sandra David; Jacqueline Brédent-Bangou; Eustase Janky

doi:10.1016/j.ejogrb.2005.06.029

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Calciuria and preeclampsia: a case-control study.

Valérie Szmidt-Adjidé·Françoise Vendittelli·Sandra David·Jacqueline Brédent-Bangou·Eustase Janky

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Abstract

OBJECTIVE: The aim of this study was to compare calciuria of preeclamptic cases to normotensive controls among pregnant women hospitalized in the French West Indies obstetrics department. STUDY DESIGN: This case-control study included 47 preeclamptic women and 50 controls. The main outcome was 24h urinary calcium excretion rate. Serum levels of creatinine, calcium and uric acid were also analyzed. A logistic regression analysis has been performed to investigate the relationship between hypocalciuria and preeclampsia after having taken into account prognostic preeclampsia factors and pertinent clinical criteria. RESULTS: Women with preeclampsia had significantly lower calciuria than normotensive patients (1.5 mmol/24h+/-1.0 versus 6.0 mmol/24h+/-4.2, p=0.0001). After taking into account gestational age at hospitalization, body mass index and nulliparity, hypocalciuria was significantly associated with preeclampsia (ORa=21.74; 95% CI, 6.9-66.7). The diagnosis value of a calciuria less than 2.1 mmol/24h is interesting because of its negative predictive value (97%), but its positive predictive value is weak (42%). CONCLUSION: In our population, preeclamptic women had a calciuria significantly lower than controls.

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Adolescent Adult Calcium Creatinine Epidemiologic Methods Female Humans Pre-Eclampsia Pregnancy Uric Acid Journal Article Research Support, Non-U.S. Gov't

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Valérie Szmidt-Adjidé, Françoise Vendittelli, Sandra David, Jacqueline Brédent-Bangou, Eustase Janky. 2005-09-15. Calciuria and preeclampsia: a case-control study.. https://doi.org/10.1016/j.ejogrb.2005.06.029

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