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PubMed · 16183272

Angiogenesis inhibitors derived from thalidomide.

Tomomi Noguchi·Haruka Fujimoto·Hiroko Sano·Atsushi Miyajima·Hiroyuki Miyachi·Yuichi Hashimoto
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Abstract

5-Hydroxy-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione (5HPP-33: 10), which was obtained during our previous structural development studies on thalidomide, was revealed to possess potent anti-angiogenic activity in a human umbilical vein endothelial cell (HUVEC) assay. Thalidomide (1) and its metabolite, 5-hydroxythalidomide (5-HT: 2), which possesses a hydroxyl group at the position corresponding to that of 5HPP-33, as well as IMiDs (immunomodulatory derivatives of thalidomide: 3 and 5), also showed weak or moderate activity in the same assay.

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Angiogenesis InhibitorsEndothelium, VascularHumansStructure-Activity RelationshipThalidomideUmbilical VeinsJournal ArticleResearch Support, Non-U.S. Gov't

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Tomomi Noguchi, Haruka Fujimoto, Hiroko Sano, Atsushi Miyajima, Hiroyuki Miyachi, Yuichi Hashimoto. 2005-09-23. Angiogenesis inhibitors derived from thalidomide.. https://doi.org/10.1016/j.bmcl.2005.08.086

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