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PubMed · 16187493

Mitochondrial apoptotic pathways.

Nora Mohamad·Alicia Gutiérrez·Mariel Núñez·Claudia Cocca·Gabriela Martín·Graciela Cricco·Vanina Medina·Elena Rivera·Rosa Bergoc
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Abstract

Apoptosis or programmed cell death (PCD) is a physiological process characteristic of pluricellular organisms leading to self-destruction of the cell. It is therefore involved in development, homeostasis and host defense. However, a significant difference has been shown between mammalian cell apoptosis and non-mammalian cell apoptosis: mitochondria are implicated only in the former. Execution of PCD includes the release of several proapoptotic proteins from the intermembrane space of mitochondria. They could exert their actions through a caspase dependent as well as a caspase independent way. On the other hand, regulation of PCD is mainly given by the Bcl-2 family members, which are in turn essentially regulated by activation of death receptors and/or DNA damage. Nowadays, execution of apoptosis is better known than its regulation. Nevertheless, we are still far of a complete understanding of the apoptotic process.

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AnimalsApoptosisCaspasesCytochromes cDNA DamageEndodeoxyribonucleasesEnzyme ActivationHumansIntracellular MembranesMitochondriaModels, BiologicalNecrosisPhosphorylationProtein Structure, TertiaryProto-Oncogene Proteins c-bcl-2Journal ArticleResearch Support, Non-U.S. Gov'tReview

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Nora Mohamad, Alicia Gutiérrez, Mariel Núñez, Claudia Cocca, Gabriela Martín, Graciela Cricco, Vanina Medina, Elena Rivera, Rosa Bergoc. 2005. Mitochondrial apoptotic pathways.. https://pubmed.ncbi.nlm.nih.gov/16187493/

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