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Robust trend tests for genetic association using matched case-control design.

Gang Zheng·Xin Tian·ACCESS Research Group
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Abstract

Trend tests for genetic association using a matched case-control design are studied, which allows for a variable number of controls per case. However, the tests depend on the scores based on the underlying genetic model, thus it may result in substantial loss of power when the model is misspecified. Since the mode of inheritance may be unknown for complex diseases, robust trend tests in matched case-control studies are developed. Simulation is conducted to compare the trend tests and the robust trend tests under various genetic models. The results are applied to detect candidate-gene association using an example from a case-control aetiologic study of sarcoidosis.

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Black PeopleCase-Control StudiesComputer SimulationFemaleGenetic Predisposition to DiseaseHumansImmunoglobulinsLogistic ModelsMaleModels, GeneticPolymorphism, Single NucleotideSarcoidosisWhite PeopleComparative StudyJournal ArticleResearch Support, N.I.H., Extramural

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Gang Zheng, Xin Tian, ACCESS Research Group. 2006-09-30. Robust trend tests for genetic association using matched case-control design.. https://doi.org/10.1002/sim.2278

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