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Spectral domain second-harmonic optical coherence tomography.

Marinko V Sarunic·Brian E Applegate·Joseph A Izatt
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Abstract

Optical coherence tomography (OCT) provides micrometer-scale structural imaging by coherent detection of backscattered light. Molecular contrast in OCT has been demonstrated using transient absorption, coherent anti-Stokes Raman scattering, and second-harmonic (SH) generation. The sensitivity of molecular contrast signals can be enhanced by use of Fourier domain techniques. We have constructed a spectrometer-based Fourier domain SH-OCT system for simultaneous acquisition of the fundamental and SH signals. We report a >30 dB increase in SH sensitivity over a similar time domain SH-OCT system and demonstrate contrast between cartilage and bone using collagen as the contrast agent.

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Equipment DesignEquipment Failure AnalysisImage EnhancementMicroscopy, InterferenceSpectroscopy, Fourier Transform InfraredTomography, Optical CoherenceEvaluation StudyJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S.

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Marinko V Sarunic, Brian E Applegate, Joseph A Izatt. 2005-09-15. Spectral domain second-harmonic optical coherence tomography.. https://doi.org/10.1364/ol.30.002391

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