PubMed · 16201398
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H Müller. 2005. Manual correlation.. https://pubmed.ncbi.nlm.nih.gov/16201398/
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Identifying potential lead molecules is becoming a more automated process. We review Shape Signatures, a tool that is effective and easy to use compared with most computer aided drug design techniques. Laboratory researchers can apply this in silico technique cost-effectively without the need for specialized computer backgrounds. Identifying a potential lead molecule requires database screening, and this becomes rate-limiting once the database becomes too large. The use of Shape Signatures eliminates this concern and offers molecule screening rates that are in advance of any currently available method. Shape Signatures provides a conduit for researchers to conduct rapid identification of potential active molecules, and studies with this tool can be initiated with only one bioactive lead or receptor site.
We analyze two basic aspects of a scanning near-field optical microscope (SNOM) probe's operation: (i) spot-size evolution of the electric field along the probe with and without a metal layer, and (ii) a modal analysis of the SNOM probe, particularly in close proximity to the aperture. A slab waveguide model is utilized to minimize the analytical complexity, yet provides useful quantitative results--including losses associated with the metal coating--which can then be used as design rules.
OBJECTIVE: To realize the requirement of adjacent area accuracy, axial surface physical contour and smoothness in the process of inlay computer-aided design (CAD). METHODS: A compromised method was brought forward that some assistant 3-D constraint lines from occlusion to gingiva were used to lead the inlay contour on axial corner and other characterized areas, and two perpendicular 3-D constructing lines at adjacent area were used to construct accurate 3-D configuration of this area. The axial surface was completely defined by the network of specified curves which were two constructing lines and four borders. RESULTS: Inlay axial surface was smooth, the contour was consistent with the residual tooth body and the 3-D configuration in adjacent area was accurate. CONCLUSION: It is feasible to realize the inlay axial surface accuracy, smoothness, and consistency using the method of special distributed 3-D B-Spline curve network.