RNA challenges for computational chemists.

Ilyas Yildirim; Douglas H Turner

doi:10.1021/bi051236o

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PubMed · 16201748

RNA challenges for computational chemists.

Ilyas Yildirim·Douglas H Turner

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Abstract

Some experimental results for the thermodynamics of RNA folding cannot be explained by simple pairwise hydrogen-bonding models. Such effects include the stabilities of isoguanosine-isocytidine (iG-iC) base pairs and of various 2 x 2 nucleotide internal loops. Presumably, these results can be explained by base stacking effects, which can be partitioned into Coulombic and overlap effects. We review experimental measurements that provide benchmarks for testing the approximations and theories used for modeling nucleic acids. Quantitative agreement between experiment and theory will indicate understanding of the interactions determining RNA stability and structure.

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Adenosine Chemistry Computational Biology Cytidine Guanosine Hydrogen Bonding Models, Molecular Models, Theoretical Nucleic Acid Conformation RNA Static Electricity Thermodynamics Journal Article Research Support, N.I.H., Extramural

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Ilyas Yildirim, Douglas H Turner. 2005-10-11. RNA challenges for computational chemists.. https://doi.org/10.1021/bi051236o

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