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PubMed · 16209345

[Beta3-adrenergic receptor].

Katarzyna Babol·Janusz Błasiak
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Abstract

The beta3-adrenergic receptor (beta3-AR) may play a key role in the regulation of lipid metabolism and glucose homeostasis. Adrenaline and noradrenaline beta3-AR stimulate lipolysis and thermogenesis in human fat cells and increase glucose uptake in skeletal muscle. Therefore, the beta3-AR gene may be associated with obesity and related diseases, such as type 2 diabetes, coronary heart disease and hypertension. Many studies in different ethnic groups showed an association of beta3-AR gene polymorphism with insulin resistance, obesity and its metabolic disorders such as type 2 diabetes, coronary heart disease and hypertension. A Trp64Arg mutation in the beta3-AR gene has been reported to be correlated with the occurrence of those disorders among obese. Several studies revealed also the influence of the Trp/Arg polymorphism on carcinogenesis and its contribution to the link between cancer and obesity. Since obesity is a serious problem as a civilization-related disease, it is very important to investigate genes suspected to be connected with it.

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Blood GlucoseHumansInsulin ResistanceLipolysisObesityPolymorphism, GeneticReceptors, Adrenergic, beta-3English AbstractJournal ArticleReview

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Katarzyna Babol, Janusz Błasiak. 2005. [Beta3-adrenergic receptor].. https://pubmed.ncbi.nlm.nih.gov/16209345/

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