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PubMed · 16209651

Histone structure and nucleosome stability.

Leonardo Mariño-Ramírez·Maricel G Kann·Benjamin A Shoemaker·David Landsman
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Abstract

Histone proteins play essential structural and functional roles in the transition between active and inactive chromatin states. Although histones have a high degree of conservation due to constraints to maintain the overall structure of the nucleosomal octameric core, variants have evolved to assume diverse roles in gene regulation and epigenetic silencing. Histone variants, post-translational modifications and interactions with chromatin remodeling complexes influence DNA replication, transcription, repair and recombination. The authors review recent findings on the structure of chromatin that confirm previous interparticle interactions observed in crystal structures.

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AnimalsChromatin Assembly and DisassemblyHistonesModels, MolecularNucleic Acid ConformationNucleosomesProtein Processing, Post-TranslationalJournal ArticleReview

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Leonardo Mariño-Ramírez, Maricel G Kann, Benjamin A Shoemaker, David Landsman. 2005. Histone structure and nucleosome stability.. https://doi.org/10.1586/14789450.2.5.719

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