The pre-B cell receptor and its function during B cell development.

Min Zhang; Gopesh Srivastava; Liwei Lu

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PubMed · 16212894

The pre-B cell receptor and its function during B cell development.

Min Zhang·Gopesh Srivastava·Liwei Lu

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Abstract

The process of B cell development in the bone marrow occurs by the stepwise rearrangements of the V, D, and J segments of the Ig H and L chain gene loci. During early B cell genesis, productive Ig H chain gene rearrangement leads to assembly of the pre-B cell receptor (pre-BCR), which acts as an important checkpoint at the pro-B/preB transitional stage. The pre-BCR, transiently expressed by developing precursor B cells, comprises the Ig muH chain, surrogate light (SL) chains VpreB and lambda5, as well as the signal-transducing heterodimer Ig alpha/Ig beta. Signaling through the pre-BCR regulates allelic exclusion at the Ig H locus, stimulates cell proliferation, and induces differentiation to small post-mitotic pre-B cells that further undergo the rearrangement of the Ig L chain genes. Recent advances in elucidating the key roles of pre-BCR in B cell development have provided a better understanding of normal B lymphopoiesis and its dysregulated state leading to B cell neoplasia.

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Animals B-Lymphocytes Humans Immunoglobulin Heavy Chains Membrane Glycoproteins Multiprotein Complexes Pre-B Cell Receptors Receptors, Antigen, B-Cell Signal Transduction Journal Article Research Support, Non-U.S. Gov't Review

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Min Zhang, Gopesh Srivastava, Liwei Lu. 2004. The pre-B cell receptor and its function during B cell development.. https://pubmed.ncbi.nlm.nih.gov/16212894/

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