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PubMed · 16214098

T for two: when helpers need help.

Maurizio Zanetti
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Abstract

This article discusses forms of cell cooperation involving CD4 T cells and their impact on adaptive immunity. In particular, evidence will be presented in favor of cooperation among CD4 T cells of different specificity, its molecular basis and functional significance. Th-Th cooperation, or help for helpers, will be discussed in relation to the induction of anti-tumor responses and, in converse, the generation of autoimmunity. A model is proposed where Th-Th cooperation may represent the structure/function substrate for the control of self/non-self discrimination and peripheral tolerance in vivo.

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AnimalsAutoimmunityCD4-Positive T-LymphocytesCell DifferentiationHumansImmunity, InnateLymphocyte CooperationTh1 CellsJournal ArticleResearch Support, N.I.H., ExtramuralReview

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Maurizio Zanetti. 2005. T for two: when helpers need help.. https://doi.org/10.1016/j.autrev.2005.04.001

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