Type III secretion: the bacteria-eukaryotic cell express.

Luís Jaime Mota; Isabel Sorg; Guy R Cornelis

doi:10.1016/j.femsle.2005.08.036

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Type III secretion: the bacteria-eukaryotic cell express.

Luís Jaime Mota·Isabel Sorg·Guy R Cornelis

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Abstract

Type III secretion (T3S) is an export pathway used by Gram-negative pathogenic bacteria to inject bacterial proteins into the cytosol of eukaryotic host cells. This pathway is characterized by (i) a secretion nanomachine related to the bacterial flagellum, but usually topped by a stiff needle-like structure; (ii) the assembly in the eukaryotic cell membrane of a translocation pore formed by T3S substrates; (iii) a non-cleavable N-terminal secretion signal; (iv) T3S chaperones, assisting the secretion of some substrates; (v) a control mechanism ensuring protein delivery at the right place and time. Here, we review these different aspects focusing in open questions that promise exciting findings in the near future.

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Animals Bacterial Proteins Eukaryotic Cells Gene Expression Regulation, Bacterial Gram-Negative Bacteria Gram-Negative Bacterial Infections Humans Protein Transport Virulence Journal Article Research Support, Non-U.S. Gov't Review

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Luís Jaime Mota, Isabel Sorg, Guy R Cornelis. 2005-09-08. Type III secretion: the bacteria-eukaryotic cell express.. https://doi.org/10.1016/j.femsle.2005.08.036

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