Making ATP.

Jianhua Xing; Jung-Chi Liao; George Oster

doi:10.1073/pnas.0507207102

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Making ATP.

Jianhua Xing·Jung-Chi Liao·George Oster

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Abstract

We present a mesoscopic model for ATP synthesis by F(1)F(o) ATPase. The model combines the existing experimental knowledge of the F(1) enzyme into a consistent mathematical model that illuminates how the stages in synthesis are related to the protein structure. For example, the model illuminates how specific interactions between the gamma, epsilon, and alpha(3)beta(3) subunits couple the F(o) motor to events at the catalytic sites. The model also elucidates the origin of ADP inhibition of F(1) in its hydrolysis mode. The methodology we develop for constructing the structure-based model should prove useful in modeling other protein motors.

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Adenosine Diphosphate Adenosine Triphosphate Catalytic Domain Hydrolysis Models, Theoretical Proton-Translocating ATPases Journal Article Research Support, U.S. Gov't, Non-P.H.S.

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Jianhua Xing, Jung-Chi Liao, George Oster. 2005-10-10. Making ATP.. https://doi.org/10.1073/pnas.0507207102

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