SARS Immunity and Vaccination.

Minsheng Zhu

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PubMed · 16219167

SARS Immunity and Vaccination.

Minsheng Zhu

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Abstract

Severe acute respiratory syndrome (SARS) is a serious and fatal infectious disease caused by SARS coronavirus (SARS-Cov), a novel human coronavirus. SARS-Cov infection stimulates cytokines (e.g., IL-10, IFN-gamma, IL-1, etc.) expression dramatically, and T lymphocytes and their subsets CD4(+) and CD8(+) T cells are decreased after onset of the disease. SARS-specific IgG antibody is generated in the second week and persists for a long time, whereas IgM is expressed transiently. The spike protein and neucleocapsid protein are most abundant in SARS-Cov and contribute dominantly to the antibody production during the course of disease. Spike protein, especially the ACE-2 binding region (318-510aa) is capable of producing neutralizing antibody to SARS-Cov. Neucleocapsid protein induces protective specific CTL to SARS-Cov. Therefore, applications with spike subunit, neucleocapsid subunit as well as inactivated SARS-Cov are three prospective vaccination strategies for SARS.

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Animals Antibodies, Viral Antibody Formation CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Humans Immunoglobulin G Severe acute respiratory syndrome-related coronavirus Severe Acute Respiratory Syndrome Vaccination Viral Envelope Proteins Viral Vaccines Journal Article Review

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Minsheng Zhu. 2004. SARS Immunity and Vaccination.. https://pubmed.ncbi.nlm.nih.gov/16219167/

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