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Bivariate isotonic design for dose-finding with ordered groups.

Anastasia Ivanova·Kai Wang
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Abstract

We consider the problem of dose-finding where subjects can be stratified into two populations with possibly different susceptibility to toxicity. The goal is to find the maximally tolerated dose for each population. We propose a non-parametric design for this problem. Toxicity is estimated using the bivariate isotonic regression estimator. The new design is compared with the two-sample continual reassessment method.

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Confidence IntervalsData Interpretation, StatisticalHumansMaximum Tolerated DoseMultivariate AnalysisStatistics, NonparametricComparative StudyJournal Article

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Anastasia Ivanova, Kai Wang. 2006-06-30. Bivariate isotonic design for dose-finding with ordered groups.. https://doi.org/10.1002/sim.2312

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