New paradigms for therapy for osteosarcoma.

Rajaram Nagarajan; Denis Clohisy; Brenda Weigel

doi:10.1007/s11912-005-0005-1

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New paradigms for therapy for osteosarcoma.

Rajaram Nagarajan·Denis Clohisy·Brenda Weigel

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Abstract

Osteosarcoma is a primary bone malignancy generally affecting the young, with 60% of cases occurring before the age of 25 years and the peak incidence at 15 years. Survival has improved over the past several decades, with non- metastatic disease having an approximately 70% chance of long-term survival. Unfortunately, patients with metastatic disease at diagnosis or those who have recurrent disease have a dismal prognosis, with approximately 20% surviving long term. In this review article we describe several new therapies in development for osteosarcoma. These include immune-based therapies, strategies to inhibit tumor growth, radiotherapy, and the introduction of new chemotherapies and targets.

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Antineoplastic Agents Bone Neoplasms Combined Modality Therapy Humans Immunotherapy Osteosarcoma Radiotherapy Journal Article Review

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Rajaram Nagarajan, Denis Clohisy, Brenda Weigel. 2005. New paradigms for therapy for osteosarcoma.. https://doi.org/10.1007/s11912-005-0005-1

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