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Chemo-inducible gene therapy.

James J Mezhir·Hank Schmidt·Bakhtiar Yamini·Neil N Senzer·Mitchell C Posner·Donald W Kufe·Ralph R Weichselbaum
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Abstract

Chemo-inducible cancer gene therapy is a potential new treatment for solid tumors that may in part enhance the anti-tumor effects of chemotherapy while minimizing toxicity. This approach combines viral vectors expressing cytotoxic transgenes that can be transcriptionally activated by DNA-damaging agents. The development of chemo-inducible gene therapy has numerous implications for the treatment of both localized and metastatic disease in patients with solid tumors.

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Antineoplastic AgentsCombined Modality TherapyDNADNA DamageEarly Growth Response Protein 1Genes, MDRGenetic TherapyHumansNeoplasmsPromoter Regions, GeneticTranscription, GeneticTumor Necrosis FactorsJournal ArticleReview

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BibTeXRIS

James J Mezhir, Hank Schmidt, Bakhtiar Yamini, Neil N Senzer, Mitchell C Posner, Donald W Kufe, Ralph R Weichselbaum. 2005. Chemo-inducible gene therapy.. https://doi.org/10.1097/00001813-200511000-00003

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