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Association between microarray gene expression signature and extravascular matrix patterns in primary uveal melanomas.

Michael D Onken·Amy Y Lin·Lori A Worley·Robert Folberg·J William Harbour
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Abstract

PURPOSE: To determine whether there is an association between gene expression profile and looping extravascular matrix patterns in primary uveal melanomas. DESIGN: Laboratory investigation. METHODS: Formalin-fixed, paraffin-embedded sections from 22 primary uveal melanomas that previously were analyzed by microarray gene expression profiling were stained for periodic acid-Schiff and scored in a masked fashion for the presence of looping extravascular matrix patterns. RESULTS: A strong association was observed between looping patterns and the unfavorable class 2 molecular prognostic signature (P < .001). CONCLUSIONS: Looping extravascular matrix patterns occur almost exclusively in class 2 uveal melanomas. This finding may provide new insights into the pathogenesis and management of uveal melanoma.

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Gene ExpressionGene Expression ProfilingHumansMelanomaNeoplasm ProteinsNeovascularization, PathologicOligonucleotide Array Sequence AnalysisPeriodic Acid-Schiff ReactionUveal NeoplasmsJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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Michael D Onken, Amy Y Lin, Lori A Worley, Robert Folberg, J William Harbour. 2005. Association between microarray gene expression signature and extravascular matrix patterns in primary uveal melanomas.. https://doi.org/10.1016/j.ajo.2005.04.024

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