G proteins in development.

Craig C Malbon

doi:10.1038/nrm1716

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G proteins in development.

Craig C Malbon

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Abstract

The focus of developmental biologists has expanded from the analysis of gene expression to include the analysis of cell signalling. Heterotrimeric G proteins (G proteins) mediate signalling from a superfamily of heptahelical receptors (G-protein-coupled receptors) to a smaller number of effector units that include adenylyl cyclases, phospholipase C and various ion channels. The convergence of developmental biology with cell signalling has now revealed overlaps in which G proteins mediate complex pathways in embryonic development.

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Animals Developmental Biology GTP-Binding Proteins Humans Models, Biological Morphogenesis Protein Subunits Receptors, G-Protein-Coupled Second Messenger Systems Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S.Review

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Craig C Malbon. 2005. G proteins in development.. https://doi.org/10.1038/nrm1716

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