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PubMed · 16239477

Interlinked fast and slow positive feedback loops drive reliable cell decisions.

Onn Brandman·James E Ferrell·Rong Li·Tobias Meyer
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Abstract

Positive feedback is a ubiquitous signal transduction motif that allows systems to convert graded inputs into decisive, all-or-none outputs. Here we investigate why the positive feedback switches that regulate polarization of budding yeast, calcium signaling, Xenopus oocyte maturation, and various other processes use multiple interlinked loops rather than single positive feedback loops. Mathematical simulations revealed that linking fast and slow positive feedback loops creates a "dual-time" switch that is both rapidly inducible and resistant to noise in the upstream signaling system.

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AnimalsCalcium SignalingCell Physiological PhenomenaComputer SimulationFeedback, PhysiologicalMathematicsModels, BiologicalOocytesPhenotypeSaccharomycetalesSignal TransductionSystems BiologyXenopusJournal Article

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Onn Brandman, James E Ferrell, Rong Li, Tobias Meyer. 2005-10-21. Interlinked fast and slow positive feedback loops drive reliable cell decisions.. https://doi.org/10.1126/science.1113834

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