Dermal matrix remodeling after nonablative laser therapy.

Jeffrey S Orringer; John J Voorhees; Ted Hamilton; Craig Hammerberg; Sewon Kang; Timothy M Johnson; Darius J Karimipour; Gary Fisher

doi:10.1016/j.jaad.2005.07.052

PubMed · 16243125

Dermal matrix remodeling after nonablative laser therapy.

Jeffrey S Orringer·John J Voorhees·Ted Hamilton·Craig Hammerberg·Sewon Kang·Timothy M Johnson·Darius J Karimipour·Gary Fisher

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Abstract

OBJECTIVE: Nonablative laser therapy is widely practiced for cutaneous rejuvenation. We sought to quantify dermal molecular changes after exposure of photodamaged skin to nonablative laser energy. METHODS: Nonablative laser therapy of forearm skin using either a 585-nm wavelength pulsed dye laser or a 1320-nm wavelength neodymium:yttrium-aluminum-garnet laser was performed. Serial biopsy specimens were obtained at baseline and various times after treatment. RESULTS: Statistically significant increases in type I procollagen messenger RNA expression occurred after exposure of photodamaged skin to each laser. Induction was 47% (P < .05) and 84% (P < .05) above baseline levels 1 week after laser therapy among those treated with the pulsed dye and neodymium:yttrium-aluminum-garnet lasers, respectively. Substantial induction of type III procollagen, various matrix metalloproteinases, and primary cytokines was also demonstrated. Responses with respect to all molecules studied were highly variable. LIMITATIONS: This study addresses molecular changes after a single laser exposure whereas clinically, serial treatments are often provided. CONCLUSIONS: Nonablative laser therapy may result in quantifiable alterations in molecules associated with remodeling of the dermal matrix, although responses vary greatly among patients.

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Aged Extracellular Matrix Proteins Female Humans Laser Therapy Male Middle Aged Skin Aging Skin Physiological Phenomena Journal Article Research Support, Non-U.S. Gov't

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Jeffrey S Orringer, John J Voorhees, Ted Hamilton, Craig Hammerberg, Sewon Kang, Timothy M Johnson, Darius J Karimipour, Gary Fisher. 2005-09-23. Dermal matrix remodeling after nonablative laser therapy.. https://doi.org/10.1016/j.jaad.2005.07.052

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