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PubMed · 16248286

Technology evaluation: mapatumumab, Human Genome Sciences/GlaxoSmithKline/Takeda.

Michel Vulfovich·Nabil Saba
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Abstract

Human Genome Sciences and GlaxoSmithKline, under license from Cambridge Antibody Technology, are developing mapatumumab, the intravenously administered lead from a series of human monoclonal antibody tumor necrosis factor-related apoptosis-inducing ligand receptor 1 agonists, for the potential treatment of cancer. The therapy is currently undergoing phase II clinical trials. Takeda is developing mapatumumab in Japan.

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Antibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntineoplastic AgentsApoptosisApoptosis Regulatory ProteinsCell Line, TumorClinical Trials, Phase I as TopicClinical Trials, Phase II as TopicContraindicationsDose-Response Relationship, DrugHumansMembrane GlycoproteinsNeoplasmsTNF-Related Apoptosis-Inducing LigandTumor Necrosis Factor-alphaXenograft Model Antitumor AssaysJournal ArticleReview

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Michel Vulfovich, Nabil Saba. 2005. Technology evaluation: mapatumumab, Human Genome Sciences/GlaxoSmithKline/Takeda.. https://pubmed.ncbi.nlm.nih.gov/16248286/

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