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PubMed · 16251738

A baboon model for simulating pregnancy.

Asgerally T Fazleabas
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Abstract

Estrogen and progesterone secreted by the corpus luteum regulate the function of the uterine endometrium in preparation for pregnancy. Embryonic signals superimposed on this steroid hormone-primed uterus further modulate the uterine environment to make it conducive to pregnancy. Understanding the signaling mechanisms that initiate the embryonic-maternal dialog in humans is not feasible. In an effort to elucidate the role of chorionic gonadotropin as a mediator of endometrial function in addition to its luteotrophic role, we have developed a simulated pregnant model in the baboon. Infusion of chorionic gonadotropin in a manner that mimics blastocyst transit induces major changes in the morphology and secretory activity of the endometrium. This model provides a method by which the function of various embryonic factors on endometrial can be tested in an in vivo model.

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AnimalsCatheterizationChorionic GonadotropinEndometriumFemaleModels, AnimalPapioPregnancyReproductive TechniquesJournal ArticleResearch Support, N.I.H., Extramural

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Asgerally T Fazleabas. 2006. A baboon model for simulating pregnancy.. https://doi.org/10.1385/1-59259-983-4%3A099

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