Hemoglobin degradation.

D E Goldberg

doi:10.1007/3-540-29088-5_11

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Hemoglobin degradation.

D E Goldberg

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Abstract

Hemoglobin degradation by Plasmodium is a massive catabolic process within the parasite food vacuole that is important for the organism's survival in its host erythrocyte. A proteolytic pathway is responsible for generating amino acids from hemoglobin. Each of the enzymes involved has its own peculiarities to be exploited for development of antimalarial agents that will starve the parasite or result in build-up of toxic intermediates. There are a number of unanswered questions concerning the cell biology, biochemistry and metabolic roles of this crucial pathway.

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Animals Aspartic Acid Endopeptidases Cysteine Endopeptidases Hemoglobins Metalloendopeptidases Peptide Hydrolases Plasmodium Protozoan Proteins Journal Article Research Support, Non-U.S. Gov't Review

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D E Goldberg. 2005. Hemoglobin degradation.. https://doi.org/10.1007/3-540-29088-5_11

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