[Immunological tolerance].

Hisanori Kosuge; Mitsuaki Isobe

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PubMed · 16277255

[Immunological tolerance].

Hisanori Kosuge·Mitsuaki Isobe

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Abstract

New immunosuppressive agents have significantly improved early survival after organ transplantation for patients with end-stage organ failure. However, a major problem in transplantation is continued to be graft rejection. Chronic allograft rejection threatens the long-term survival of organ transplant recipients. Therefore, induction of donor specific tolerance is very important for improving long-term survival after transplantation. The costimulatory pathways are crucial in regulating T cell activation and donor specific tolerance. The costimulatory pathways are potential therapeutic targets for inducing donor specific tolerance and improving long-term survival after transplantation.

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Hisanori Kosuge, Mitsuaki Isobe. 2005. [Immunological tolerance].. https://pubmed.ncbi.nlm.nih.gov/16277255/

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