Locked nucleic acid molecular beacons.

Lin Wang; Chaoyong James Yang; Colin D Medley; Steven A Benner; Weihong Tan

doi:10.1021/ja052498g

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Locked nucleic acid molecular beacons.

Lin Wang·Chaoyong James Yang·Colin D Medley·Steven A Benner·Weihong Tan

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Abstract

A novel LNA-MB (molecular beacon based on locked nucleic acid bases) has been designed and investigated. It exhibits very high melting temperature and is thermally stable, shows superior single base mismatch discrimination capability, and is stable against digestion by nuclease and has no binding with single-stranded DNA binding proteins. The LNA-MB will be widely useful in a variety of areas, especially for in vivo hybridization studies.

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Fluorescence Gene Expression Profiling Nucleic Acid Conformation Nucleic Acid Hybridization Nucleotides Oligonucleotide Probes Oligonucleotides Oligonucleotides, Antisense Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

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Lin Wang, Chaoyong James Yang, Colin D Medley, Steven A Benner, Weihong Tan. 2005-11-16. Locked nucleic acid molecular beacons.. https://doi.org/10.1021/ja052498g

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