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Bacterial outer membrane vesicles and the host-pathogen interaction.

Meta J Kuehn·Nicole C Kesty
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Abstract

Extracellular secretion of products is the major mechanism by which Gram-negative pathogens communicate with and intoxicate host cells. Vesicles released from the envelope of growing bacteria serve as secretory vehicles for proteins and lipids of Gram-negative bacteria. Vesicle production occurs in infected tissues and is influenced by environmental factors. Vesicles play roles in establishing a colonization niche, carrying and transmitting virulence factors into host cells, and modulating host defense and response. Vesicle-mediated toxin delivery is a potent virulence mechanism exhibited by diverse Gram-negative pathogens. The biochemical and functional properties of pathogen-derived vesicles reveal their potential to critically impact disease.

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AnimalsCell WallGram-Negative BacteriaGram-Negative Bacterial InfectionsHumansJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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Meta J Kuehn, Nicole C Kesty. 2005-11-15. Bacterial outer membrane vesicles and the host-pathogen interaction.. https://doi.org/10.1101/gad.1299905

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