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SUMO keeps a check on recombination during DNA replication.

Helle D Ulrich·Sabina Vogel·Adelina A Davies
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Abstract

The small ubiquitin-related modifier SUMO plays an important role in the maintenance of genome stability. Accordingly, DNA replication, repair and recombination factors as well as mediators of chromosome dynamics and cohesion are among its many targets. Attachment of SUMO can modulate the properties of the modified proteins by affecting localization, conformation, stability or enzymatic activity, but often its mechanism of action remains poorly defined. Recent findings demonstrate how SUMO modification of PCNA, the processivity clamp for replicative DNA polymerases, prevents unscheduled recombination during DNA replication by means of directly enhancing physical interactions with an anti-recombinogenic helicase, Srs2. This review highlights how the SUMO conjugation system exerts its effect on the replication fork and discusses the implications for ubiquitin-dependent DNA damage tolerance.

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AnimalsDNA HelicasesDNA ReplicationProliferating Cell Nuclear AntigenRecombination, GeneticS PhaseSaccharomyces cerevisiae ProteinsSmall Ubiquitin-Related Modifier ProteinsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Helle D Ulrich, Sabina Vogel, Adelina A Davies. 2005-12-20. SUMO keeps a check on recombination during DNA replication.. https://doi.org/10.4161/cc.4.12.2194

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