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Cationic liposomes for gene delivery.

Sérgio Simões·Ana Filipe·Henrique Faneca·Miguel Mano·Nuno Penacho·Nejat Düzgünes·Maria Pedroso de Lima
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Abstract

Cationic liposome-DNA complexes (lipoplexes) constitute a potentially viable alternative to viral vectors for the delivery of therapeutic genes. This review will focus on various parameters governing lipoplex biological activity, from their mode of formation to in vivo behaviour. Particular emphasis is given to the mechanism of interaction of lipoplexes with cells, in an attempt to dissect the different barriers that need to be surpassed for efficient gene expression to occur. Aspects related to new trends in the formulation of lipid-based gene delivery systems aiming at overcoming some of their limitations will be covered. Finally, examples illustrating the potential of cationic liposomes in clinical applications will be provided.

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AnimalsCationsCell MembraneClinical Trials as TopicCystic FibrosisCytoplasmDNAForecastingGene Expression RegulationGenetic TherapyHumansLiposomesNeoplasmsNuclear EnvelopeParticle SizeTransfectionJournal ArticleReview

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BibTeXRIS

Sérgio Simões, Ana Filipe, Henrique Faneca, Miguel Mano, Nuno Penacho, Nejat Düzgünes, Maria Pedroso de Lima. 2005. Cationic liposomes for gene delivery.. https://doi.org/10.1517/17425247.2.2.237

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