Structures for amyloid fibrils.

O Sumner Makin; Louise C Serpell

doi:10.1111/j.1742-4658.2005.05025.x

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PubMed · 16302960

Structures for amyloid fibrils.

O Sumner Makin·Louise C Serpell

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Abstract

Alzheimer's disease and Creutzfeldt-Jakob disease are the best-known examples of a group of diseases known as the amyloidoses. They are characterized by the extracellular deposition of toxic, insoluble amyloid fibrils. Knowledge of the structure of these fibrils is essential for understanding the process of pathology of the amyloidoses and for the rational design of drugs to inhibit or reverse amyloid formation. Structural models have been built using information from a wide variety of techniques, including X-ray diffraction, electron microscopy, solid state NMR and EPR. Recent advances have been made in understanding the architecture of the amyloid fibril. Here, we describe and compare postulated structural models for the mature amyloid fibril and discuss how the ordered structure of amyloid contributes to its stability.

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Alzheimer Disease Amyloid Amyloidosis Creutzfeldt-Jakob Syndrome Humans Models, Molecular Molecular Structure Protein Conformation X-Ray Diffraction Journal Article Research Support, Non-U.S. Gov't Review

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O Sumner Makin, Louise C Serpell. 2005. Structures for amyloid fibrils.. https://doi.org/10.1111/j.1742-4658.2005.05025.x

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