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Immunologic memory in cutaneous leishmaniasis.

Phillip Scott
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Abstract

Leishmania major infections induce solid immunity to reinfection. Experimental studies in mice indicate that the CD4+ T cells responsible for this immunity include two populations: parasite-dependent T effector cells and parasite-independent central memory T (Tcm) cells. While there currently is no vaccine for leishmaniasis, the existence of a long-lived population of Tcm cells that does not require the continued presence of live parasites suggests that a vaccine that expands these cells might be efficacious.

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AnimalsCD4-Positive T-LymphocytesImmunologic MemoryLeishmania majorLeishmaniasis, CutaneousJournal ArticleResearch Support, N.I.H., ExtramuralReview

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BibTeXRIS

Phillip Scott. 2005. Immunologic memory in cutaneous leishmaniasis.. https://doi.org/10.1111/j.1462-5822.2005.00626.x

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