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PubMed · 16312151

Polymer-assisted solution-phase chemical library synthesis.

John J Parlow
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Abstract

Polymer-assisted solution-phase (PASP) synthesis has become a prevalent method for the parallel synthesis of chemical libraries. PASP methodology enables the chemist to prepare libraries of compounds more quickly and efficiently than previously. PASP technology encompasses a number of purification techniques for intermediate and final product purification. This methodology continues to progress, providing the practitioner with a broad range of ingenious purification methods, enabling multi-step syntheses of complex compounds. This review covers significant new advances in the use of tagged-reagents/substrates, resin capture-release techniques and PASP multi-step synthesis, some of which incorporate microwave heating and automation.

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AnthracenesAutomationChelating AgentsChemical PrecipitationCombinatorial Chemistry TechniquesCyclic N-OxidesIndicators and ReagentsIon Exchange ResinsMicrowavesOrganic ChemicalsPhosphinesPolymersSolutionsJournal ArticleReview

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John J Parlow. 2005. Polymer-assisted solution-phase chemical library synthesis.. https://pubmed.ncbi.nlm.nih.gov/16312151/

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