Neovascularization and mast cells with tryptase activity increase simultaneously with pathologic progression in human endometrial cancer.

Domenico Ribatti; Nicoletta Finato; Enrico Crivellato; Andrea Marzullo; Domenica Mangieri; Beatrice Nico; Angelo Vacca; Carlo A Beltrami

doi:10.1016/j.ajog.2005.04.055

PubMed · 16325597

Neovascularization and mast cells with tryptase activity increase simultaneously with pathologic progression in human endometrial cancer.

Domenico Ribatti·Nicoletta Finato·Enrico Crivellato·Andrea Marzullo·Domenica Mangieri·Beatrice Nico·Angelo Vacca·Carlo A Beltrami

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Abstract

OBJECTIVE: In vitro and in vivo studies have linked mast cell (MC) degranulation and activation with angiogenesis and neovascularization. This assumption is partially supported by the close anatomic association between MC and the vasculature and the recruitment of these cells during tumor growth. The aim of this study was to correlate the extent of angiogenesis with the number of MC expressing tryptase in human endometrial adenocarcinoma. STUDY DESIGN: Tissues from human endometrial hyperplasia and endometrial adenocarcinoma were investigated immunohistochemically, using 2 murine monoclonal antibodies against the endothelial cell marker CD31 and the MC marker tryptase. RESULTS: Angiogenesis, measured as microvessel counts, was highly correlated with MC tryptase-positive cell counts and that these parameters increase in agreement with tumor progression. CONCLUSION: These results suggest that angiogenesis in endometrial cancer increases with tumor progression and that angiogenic tryptase secreted by host MC cooperate in its induction.

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Adenocarcinoma Cell Degranulation Disease Progression Endometrial Neoplasms Female Humans Immunohistochemistry Mast Cells Neoplasm Invasiveness Neovascularization, Pathologic Serine Endopeptidases Tryptases Journal Article Research Support, Non-U.S. Gov't

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Domenico Ribatti, Nicoletta Finato, Enrico Crivellato, Andrea Marzullo, Domenica Mangieri, Beatrice Nico, Angelo Vacca, Carlo A Beltrami. 2005. Neovascularization and mast cells with tryptase activity increase simultaneously with pathologic progression in human endometrial cancer.. https://doi.org/10.1016/j.ajog.2005.04.055

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