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PubMed · 16326413

High-dose methotrexate-associated acute renal failure may be an avoidable complication.

Cheuk-Ming Fong·Anselm C W Lee
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Abstract

A 17-year-old boy with acute lymphoblastic leukemia developed acute renal failure within 48 h of an intravenous high-dose methotrexate (5 g/m2) infusion. His renal function returned to baseline 14 days later with supportive care, folinic acid rescue, and urinary alkalinization. A retrospective review revealed that the patient had been exposed to iopamidol, an intravenous contrast medium, on the day prior to the commencement of methotrexate treatment. Methotrexate-associated nephropathy is a rare complication in pediatric oncology, and a review of the literature suggests that exposure to nephrotoxic agents may be a significant but perhaps underrecognized risk factor for its development.

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Acute Kidney InjuryAdolescentAntineoplastic Combined Chemotherapy ProtocolsBone Marrow TransplantationHumansLeucovorinMaleMethotrexatePrecursor Cell Lymphoblastic Leukemia-LymphomaTreatment OutcomeCase ReportsJournal Article

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Cheuk-Ming Fong, Anselm C W Lee. High-dose methotrexate-associated acute renal failure may be an avoidable complication.. https://doi.org/10.1080/08880010500313421

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