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PubMed · 16331052

Keratitis associated with multiple endocrine deficiency.

Mehrdad Mohammadpour·Mohammad-Ali Javadi
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Abstract

PURPOSE: To report an 8-year-old girl with bilateral progressive visual loss and photophobia secondary to stem cell deficiency as a result of multiple endocrine deficiency. METHODS: A case report and review of medical literature. RESULTS: The patient suffered from severe photophobia and decreased visual acuity since May 2000. Despite multiple outpatient visits, no definite cause was found, and conservative treatments failed. On slit-lamp examination severe meibomian gland dysfunction, loss of eyelashes, decreased tear meniscus, diffuse corneal vascularization, and delayed punctate fluorescein staining of corneal epithelium were detected. She had also episodes of hypotension, oral candidiasis, and seizures. Her systemic work up revealed multiple endocrine deficiency (Addison disease and hypoparathyroidism). Hormone replacement therapy with fludrocortisone and oral calcium accompanied by punctual occlusion led to significant clinical recovery. CONCLUSION: In a pediatric patient with diffuse corneal vascularization and no definite cause, systemic workup should be done to rule out multiple endocrine deficiencies. Treatment consists of hormone replacement therapy and management of the dry eye.

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Anti-Inflammatory AgentsCalciumChildCorneaDrug Therapy, CombinationFemaleFludrocortisoneHormone Replacement TherapyHumansKeratitisPhotophobiaPolyendocrinopathies, AutoimmuneVisual AcuityCase ReportsJournal Article

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Mehrdad Mohammadpour, Mohammad-Ali Javadi. 2006. Keratitis associated with multiple endocrine deficiency.. https://doi.org/10.1097/01.ico.0000179928.20522.3a

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