Protein complexes regulating Arp2/3-mediated actin assembly.

Theresia E B Stradal; Giorgio Scita

doi:10.1016/j.ceb.2005.12.003

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Protein complexes regulating Arp2/3-mediated actin assembly.

Theresia E B Stradal·Giorgio Scita

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Abstract

Key steps in regulating actin dynamics are the de novo nucleation and elongation of actin filaments, which can be catalysed by a limited number of proteins and protein complexes. Among these, Arp2/3 complex and formins are the best studied. Arp2/3-complex activity is controlled through signalling-dependent association with nucleation-promoting factors, such as the WASP/WAVE family proteins. A common theme for these molecules, which is well established for WAVEs but is only just beginning to emerge for WASPs, is that they act as coincident detectors of a variety of signalling pathways through the formation of large multi-molecular complexes.

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Theresia E B Stradal, Giorgio Scita. 2005-12-15. Protein complexes regulating Arp2/3-mediated actin assembly.. https://doi.org/10.1016/j.ceb.2005.12.003

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