PubMed · 16352099
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Franklin Rosenfeldt. 2003. Why publish hypothesis papers?. https://doi.org/10.1046/j.1444-2892.2003.00190.x
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Precision oncology relies on integrating tumour fraction, variant allele frequency, clonal haematopoiesis of indeterminate potential assessment, pathogenicity, and clinical context into next-generation sequencing interpretation, enabling biologically informed and clinically meaningful treatment decisions while reducing the risk of overinterpreting nontumour or nonactionable genomic alterations.