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PubMed · 16359941

Gap junctions in skeletal development and function.

Joseph P Stains·Roberto Civitelli
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Abstract

Gap junctions play a critical role in the coordinated function and activity of nearly all of the skeletal cells. This is not surprising, given the elaborate orchestration of skeletal patterning, bone modeling and subsequent remodeling, as well as the mechanical stresses, strains and adaptive responses that the skeleton must accommodate. Much remains to be learned regarding the role of gap junctions and hemichannels in these processes. A common theme is that without connexins none of the cells of bone function properly. Thus, connexins play an important role in skeletal form and function.

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Amino Acid SequenceAnimalsBody PatterningBone DevelopmentBone and BonesCell CommunicationChondrocytesConnexin 43ConnexinsGap JunctionsGene Expression Regulation, DevelopmentalHumansMiceMice, TransgenicModels, BiologicalMolecular Sequence DataOsteoblastsOsteocytesJournal ArticleReview

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Joseph P Stains, Roberto Civitelli. 2005-11-14. Gap junctions in skeletal development and function.. https://doi.org/10.1016/j.bbamem.2005.10.012

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