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PubMed · 16364458

Stressed-out endogenous cannabinoids relieve pain.

Christopher W Vaughan
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Abstract

A variety of physical and psychological stressors induce analgesia by activating descending systems that project from the brain to the spinal cord. This stress-induced analgesia (SIA) is mediated by distinct opioid- and non-opioid-dependent mechanisms. New evidence suggests that non-opioid SIA is mediated by two independent endocannabinoids within the midbrain. Furthermore, novel agents that disrupt breakdown of these endocannabinoids enhance non-opioid SIA and pave the way for novel therapies.

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AnalgesiaAnimalsCannabinoidsHumansPainPeriaqueductal GrayReceptors, CannabinoidStress, PsychologicalJournal ArticleReview

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BibTeXRIS

Christopher W Vaughan. 2005-12-20. Stressed-out endogenous cannabinoids relieve pain.. https://doi.org/10.1016/j.tips.2005.11.011

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