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PubMed · 16366531

pH-sensitive vesicles based on a biocompatible zwitterionic diblock copolymer.

Jianzhong Du·Yiqing Tang·Andrew L Lewis·Steven P Armes
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Abstract

Highly biocompatible pH-sensitive diblock copolymer vesicles were prepared from the self-assembly of a biocompatible zwitterionic copolymer, poly[2-(methacryloyloxy)ethyl phosphorylcholine-block-2-(diisopropylamino)ethyl methacrylate], PMPC-b-PDPA. Vesicle formation occurred spontaneously by adjusting the solution pH from pH 2 to above 6, with the hydrophobic PDPA chains forming the vesicle walls. Transmission electron microscopy (TEM), dynamic laser light scattering (DLS), and UV-visible absorption spectrophotometry were used to characterize these vesicles. Gold nanoparticle-decorated vesicles were also obtained by treating the vesicles with HAuCl4, followed by NaBH4.

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Biocompatible MaterialsHydrogen-Ion ConcentrationHydrophobic and Hydrophilic InteractionsMethacrylatesPhosphorylcholinePolymethacrylic AcidsJournal ArticleResearch Support, Non-U.S. Gov't

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Jianzhong Du, Yiqing Tang, Andrew L Lewis, Steven P Armes. 2005-12-28. pH-sensitive vesicles based on a biocompatible zwitterionic diblock copolymer.. https://doi.org/10.1021/ja056514l

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