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PubMed · 16370384

Technology evaluation: denosumab, Amgen.

Bo Abrahamsen·Andy Y T Teng
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Abstract

Amgen, as part of its program targeting the RANK/RANKL/ osteoprotegerin pathway, is developing denosumab, a fully human monoclonal antibody, delivered subcutaneously, targeting the receptor activator of nuclear factor-kappaB ligand, for the potential treatment of diseases associated with bone loss, such as osteoporosis and bone metastases. The antibody is currently undergoing phase III clinical trials.

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Antibodies, MonoclonalAntibodies, Monoclonal, HumanizedClinical Trials as TopicDenosumabDrug Evaluation, PreclinicalDrug IndustryHumansPatents as TopicRANK LigandJournal Article

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Bo Abrahamsen, Andy Y T Teng. 2005. Technology evaluation: denosumab, Amgen.. https://pubmed.ncbi.nlm.nih.gov/16370384/

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