Random genetic drift and gamete frequency.

Shuhei Mano

doi:10.1534/genetics.104.036897

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Random genetic drift and gamete frequency.

Shuhei Mano

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Abstract

An analytic expression of conditional expectation of transient gamete frequency, given that one of the two loci remains polymorphic, is obtained in terms of the diffusion process by calculating the moments of the distribution. Using this expression, a model where linkage disequilibrium is introduced by a single mutation is considered. The conditional expectation of the gamete frequency given that the locus with the mutant allele remains polymorphic is presented. The behavior is significantly different from the monotonic decrease observed in the deterministic model without random genetic drift.

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Computer Simulation Genetic Drift Genetics, Population Germ Cells Linkage Disequilibrium Models, Genetic Polymorphism, Genetic Comparative Study Journal Article

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Shuhei Mano. 2005. Random genetic drift and gamete frequency.. https://doi.org/10.1534/genetics.104.036897

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