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PubMed · 16371946

Oligodendrocyte wars.

William D Richardson·Nicoletta Kessaris·Nigel Pringle
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Abstract

Oligodendrocyte precursors first arise in a restricted ventral part of the embryonic spinal cord and migrate laterally and dorsally from there. Later, secondary sources develop in the dorsal cord. Normally, the ventrally-derived precursors compete with and suppress their dorsal counterparts. There are also ventral and dorsal sources in the forebrain, but here the more dorsal precursors prevail and the ventral-most lineage is eliminated during postnatal life. How do the different populations compete and what is the outcome of the competition? Do different embryonic origins signify different functional subgroups of oligodendrocyte?

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AnimalsCell DifferentiationCentral Nervous SystemEmbryonic DevelopmentOligodendrogliaStem CellsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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William D Richardson, Nicoletta Kessaris, Nigel Pringle. 2006. Oligodendrocyte wars.. https://doi.org/10.1038/nrn1826

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