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Microinjection of ritanserin into the dorsal hippocampal CA1 and dentate gyrus decrease nociceptive behavior in adult male rat.

E Soleimannejad·S Semnanian·Y Fathollahi·N Naghdi
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Abstract

Prenatal 5HT depletion causes a significant decrease in the level of nociceptive sensitivity during the second phase of the formalin test behavioral response. These experiments were designed to test whether blocking 5HT2A/2c receptors in the CA1 region of the hippocampus and dentate gyrus would decrease nociceptive behaviors induced by a peripheral noxious stimulus formalin as an animal model of unremitting human being. The 5HT2A/2c receptor antagonist ritanserin (2, 4 and 8 microg/0.5 microl) was injected into the CA1 area and dentate gyrus of behaving rats 5 min before subcutaneous injection of formalin irritant. Nociceptive behaviors in both phases of the formalin test were significantly decreased by ritanserin (4 and 8 microg/0.5 microl) and ritanserin had no effect at 2 microg/0.5 microl. These results support the hypothesis that the hippocampal formation may modify the processing of incoming nociceptive information and that 5HT2A/2c receptor-sensitive mechanisms in the hippocampus may play a role in nociception and/or the expression of related behaviors.

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AnimalsBehavior, AnimalDisease Models, AnimalDose-Response Relationship, DrugHippocampusMaleMicroinjectionsPainPain MeasurementRatsRats, WistarRitanserinSerotonin AntagonistsTime FactorsComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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E Soleimannejad, S Semnanian, Y Fathollahi, N Naghdi. 2005-12-27. Microinjection of ritanserin into the dorsal hippocampal CA1 and dentate gyrus decrease nociceptive behavior in adult male rat.. https://doi.org/10.1016/j.bbr.2005.11.011

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