PubMed · 16379872
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J Wittes. 2000. Subgroups time to change the question?. https://doi.org/10.1054/ebcm.2000.0343
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Precision oncology relies on integrating tumour fraction, variant allele frequency, clonal haematopoiesis of indeterminate potential assessment, pathogenicity, and clinical context into next-generation sequencing interpretation, enabling biologically informed and clinically meaningful treatment decisions while reducing the risk of overinterpreting nontumour or nonactionable genomic alterations.