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Caveolins in vascular smooth muscle: form organizing function.

Christopher D Hardin·Johana Vallejo
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Abstract

Caveolae are becoming increasingly recognized as an important organizational structure for a variety of signal and energy-transducing systems in vascular smooth muscle (VSM). In this review, we discuss the emerging role of the caveolins in organizing and modulating the basic functions of smooth muscle: contraction, growth/proliferation, and the energetic support systems that support these functions. With clear alterations in cell metabolism and function in VSM with altered caveolin-1 (Cav-1) protein expression and with cardiovascular abnormalities associated with Cav-1 null mice, the caveolin family of proteins may play an important role in the function and dysfunction of VSM.

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AnimalsAtherosclerosisCaveolinsCell DifferentiationCell ProliferationHumansMuscle ContractionMuscle, Smooth, VascularSignal TransductionJournal ArticleReview

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BibTeXRIS

Christopher D Hardin, Johana Vallejo. 2006-01-04. Caveolins in vascular smooth muscle: form organizing function.. https://doi.org/10.1016/j.cardiores.2005.11.024

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